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The Integrated Biomedical Science Graduate Program (IBGP) is the only college-wide graduate program within the OSU College of Medicine and Public Health. It was developed to provide both breadth and depth of high quality training to prepare its graduates for successful careers in biomedical research. This is achieved through an efficient, rigorous curriculum designed specifically for graduate students in this program. The theme of the IBGP is "The Biology of Human Disease," and this is reflected in the topics of the Core Curriculum. These topics span the range from biochemistry and molecular biology through cell, tissue and organ biology, to integrated organ systems. This material is always presented so that the student will understand how the complex interactions of these mechanisms at different levels of organization lead to the expression of human diseases. Less extensive courses during the first year broaden the basic educational training for the students. These include Biomedical Research Ethics, Animal Models of Human Diseases, Bioinformatics, Research Problem Solving, and Biostatistics. The latter course has several modules that can be combined in different ways to meet the specific needs of individual students.
During the second year students are taught essential aspects of grant writing by faculty who are experienced and successful in writing research grant proposals. Fundamentals of Grant Writing-1, given during autumn, explains the processes involved in the identification of an appropriate funding agency and the preparation of a grant proposal. During winter, students write a research proposal based on their dissertation research project under the guidance of their dissertation advisor. They are also provided assistance on statistical aspects of this proposal in the course Statistical Aspects of Grant Writing. This grant proposal is submitted to a mock peer review panel on which they participate as study section members in Fundamentals of Grant Writing-2. During summer quarter of year two the revised grant proposal serves as the written document for the Candidacy Examination which they must defend orally. Research training begins with the first Summer Quarter both as a course in research techniques and resources, and as a rotation in the laboratory of a potential advisor chosen by the student. Students also choose the laboratories for their research rotations during the next three quarters. By the end of the first year the students will have chosen a Dissertation Advisor under whom they will conduct their dissertation research. Although there are no department-based graduate programs in the College, several departments offer high level, specialized graduate courses in their disciplines that are presented by IBGP graduate faculty, and are available to IBGP students. To round out their education some students may also take some of the numerous graduate courses offered by departments on campus outside of the College of Medicine and Public Health. To help the student focus his/her advanced graduate studies, the IBGP has eleven primary Areas of Research Emphasis, the IBGP has eleven primary Areas of Research Emphasis, in each of which there are several graduate faculty members who are outstanding researchers. For each of these areas there is a suggested curriculum that if completed will be recognized on the student’s graduation transcript as an area of graduate specialization. This will be in addition to the graduate major designated as Integrated Biomedical Science. There is an optional secondary area in Translational Research for students wishing to move more basic scientific information from their primary area towards clinical applications. This curriculum is extremely flexible and allows students to study select courses from the preclinical and clinical medical curricula that apply to their dissertation research. This should increase their time to graduation by only 3 months. Students take the Candidacy Examination by the end of the second year, and it is expected that they will complete their dissertation research and defend their dissertations within five years of entering the program. Throughout their training students will have abundant opportunities to receive close mentoring by the IBGP Graduate Faculty. There are several IBGP seminars at which students and faculty can present their own research, and hear international authorities present topics related to the themes of the modules in the Core Course. All of this is in addition to the individual instruction by the student’s Dissertation Advisor and Advisory Committee in the research discipline in which he/she has chosen to focus. The final goal is to prepare the students to become some of the best biomedical scientists who will further our understanding of the biology of human diseases.
 *This course is optional and not a requirement of the core curriculum
*Required advanced courses in the Area of Research Interest total 6 credit hours †Required advanced seminars in the Area of Research Interest total 9 credit hours ††IBGP-851 is required for only one quarter, and may be taken any year after the first. CURRICULUM SUBSEQUENT TO SECOND YEAR
†IBGP-851 is required for only one quarter, and may be taken any year after the first. ††Required advanced seminars in the Area of Research Interest total 9 credit hours *Required advanced courses in the Area of Research Interest total 6 credit hours **Students must give a one-hour seminar based on their dissertation research at least once in IBGP-797.02, usually in their senior year. FIRST YEAR CORE COURSES SUMMER QUARTER Research
Techniques and Resources Course Coordinators: Faculty: V. Bergdall, DVM, DACLAM, Associate Professor, ULAR R. T. Boyd, Ph.D., Associate Professor, Neuroscience R. W. Burry, Ph.D., Associate Professor, Neuroscience S. D. Jewell, Ph.D., Research Scientist, Pathology R. Munson, Ph.D., Professor, Pediatrics, Molecular Virology, Immunology, and Medical Genetics P. Schmalbrock, Associate Professor, Radiology J. R. Van Brocklyn, Ph.D., Assistant Professor, Pathology D. D. Vandre, Ph.D., Associate Professor, Department of Physiology and Cell Biology W. J. Waldman, Ph.D., Associate Professor, Pathology Class Time: 3 days per week; each session 1 hr. lecture
and 3 hrs. lab Textbook: Molecular Biology of the Cell, Fourth Edition; Editors: B. Alberts et al. Garland Science, 2002 Synopsis: This course was designed to prepare the students for their laboratory rotations and dissertation research by covering three general areas: (1) Laboratory safety; (2) Commonly used laboratory techniques; (3) Research resources available to the students. Students can receive credit for lectures only by registering in IBGP-805.02. Outline of Topics Laboratory Safety
Laboratory Animals
Microbiology
Cell & Tissue Culture
Immunological Assays
Molecular Biology
Histology
Microscopy
Direct and Indirect Immunocytochemistry (ICC)
Research Resources
Faculty
Research Miniseminars Course Coordinator: Virginia M. Sanders, Ph.D., Professor Department Molecular Virology, Immunology and Medical Genetics Faculty: Faculty of the Integrated Biomedical Science Graduate Program Class Time: 2 days per week; each session 1 hr. with four faculty presentations Synopsis: The IBGP requires that during the first year students rotate through at least three different research laboratories so that students can become familiar with both the research and laboratory environment of potential Dissertation Advisors. This also gives them an opportunity to learn research techniques that will be valuable for them in their dissertation research. It is critically important that students are familiar with research opportunities in the laboratories of the IBGP faculty to make informed decisions for both rotations and dissertation research. This course will provide a structured system of presentations by IBGP faculty members to optimize the information that students will have about potential laboratory options available to them.
Biology
of Human Disease-I Course Coordinator: Virginia M. Sanders, Ph.D. Professor Department of Molecular Virology, Immunology and Medical Genetics Synopsis: This is the first of a rigorous three-course sequence. Each course spans one quarter (ten weeks) and consists of four modules, each with its own theme. Most of the classes are lectures, but there are some group discussions and demonstrations. The overall goal is to provide sufficient breadth and depth of information for the students to understand at several levels of organization the causes and biological mechanisms responsible for the expression of different types of human diseases. This is done by first providing information about normal structure and function, and then explaining how abnormalities in these lead to disease. During Autumn Quarter mechanisms involving nucleic acid and protein biochemistry, molecular genetics, and gene expression are covered. IBGP students register for all four (4) modules in IBGP 701.05. Non-IBGP students can also register for IBGP 701.05 or take individual modules. Module 1 Module Director: Lai
Chu Wu, Ph.D. Associate Professor Department of Molecular and Cellular Biochemistry Textbooks: Molecular Biology of the Cell, Fourth Edition, Editors: B. Alberts et al., Garland Science, 2002 Synopsis: Since the double helix model of DNA structure was proposed fifty years ago, much has been learned about the human genome including its nucleotide sequence and how the 3.3 billion base pair DNA is condensed and packaged into chromosomes. Inside the nucleus, chromatins are not merely stagnant mega-structures, but their conformation can alter according to specific genetic programs of cells and with cell cycle progression. Chromatin remodeling is important in DNA replication and DNA repair, as well as for differential expression of genes in different cells. This first module aims to provide a comprehensive account of the structure of the genetic materials, and processes of DNA replication and repair, whose fidelity and efficiency ensure the faithful transmission of genetic information and stability of the genome. The lectures are designed to provide fundamental concepts with emphasis on the strategies and approaches used for the scientific discoveries, and to discuss the technical application of the information obtained. The overall goal is to provide a foundation to our understanding of the molecular mechanisms of human diseases. Outline Genetic materials and Biochemistry of deoxyribonucleic acids (Lai-Chu Wu, Ph.D.)
Chromosome Structures (Mark Parthun, Ph.D.)
DNA replication (Debbie Parris, Ph.D./ Lai-Chu Wu, Ph.D)
DNA damage and repair (Altaf Wani, Ph.D.)
Definition and classification of disease (Allan Yates, MD, PhD)
Module 2 Module Director: Jeff
Kuret, Ph.D. Professor, Department of Molecular and
Cellular Biochemistry Charles E. Bell, Ph.D., Assistant Professor, Department of Molecular and Cellular Biochemistry Charles L. Brooks, Ph.D., Professor, Department of Veterinary Biosciences, College of Veterinary Medicine Kari Green-Church, Ph.D., Campus Chemical Instrument Center Jeff Kuret, Ph.D., Professor, Department of Molecular and Cellular Biochemistry Jiyan Ma, Ph.D., Assistant Professor, Department of Molecular and Cellular Biochemistry Christopher Phiel, Ph.D., Assistant Professor, Department of Pediatrics, Children’s Research Institute Dale Vandre, Ph.D., Associate Professor, Department of Physiology & Cell Biology Heifeng Wu, M.D, Assistant Professor, Department of Pathology Textbook: Molecular Biology of the Cell, Fourth Edition, Editors: B. Alberts et al. Garland Science, 2002 Synopsis: Protein molecules are the fundamental building blocks of the cell. Encoded by genes, and assembled from constituent amino acids, proteins achieve remarkable diversity in structure and biological function. Additional diversity and specificity of function is achieved by postranslational modification of polypeptide chains. This module focuses on basic principals of protein structure and function, and provides a general overview of the field from chemistry of constituent amino acids to catalytic activities associated with the folded state. Methods of protein characterization also will be discussed. Disease examples of protein function and misfunction will include diabetes, Alzheimer's disease, prion-mediated disease, and diseases of blood coagulation . Outline Primary structure
Protein folding I: Secondary structure Protein folding II: Tertiary structure
Protein folding III: Quaternary structure
Posttranslational modifications
Protein Purification Ligand-protein interactions
Protein turnover
Diseases associated with protein folding
Module 3 Module Director: Gustavo W. Leone, Ph.D., Assistant Professor, Molecular Virology, Immunology and Medical Genetics Faculty: Harold Fisk, Ph.D., Assistant Professor, Department of Medical Genetics Lawrence Kirschner, M.D., Ph.D., Assistant Professor, Department of Pathology Gustavo W. Leone, Ph.D., Assistant Professor, Department of Molecular Virology, Immunology and Medical Genetics Tatsuya Nakamura, Ph.D., Assistant Professor, Department of Molecular Virology, Immunology and Medical Genetics Yuri Pekarski, Ph.D., Assistant Professor, Department of Molecular Virology, Immunology and Medical Genetics Amanda Toland, Ph.D., Assistant Professor, Department of Molecular Virology, Immunology and Medical Genetics Michael Weinstein, Ph.D., Assistant Professor, Department of Molecular Genetics
Textbook: Molecular Biology of the Cell, Fourth Edition, Editors: B. Alberts et al. Garland Science, 2002 Synopsis: In late June 2000 the Human Genome Project public consortium announced that it had assembled a "working draft" of the sequence of the human genome -- the genetic blueprint for a human being. A great profusion of discoveries about the genetic basis of diseases already has resulted from the HGP. Initially, these discoveries related to relatively rare conditions, but increasingly the same powerful approaches are uncovering hereditary factors in diabetes and other common illnesses. Gene alterations are responsible for an estimated 5,000 clearly hereditary diseases. This module is designed to provide students with a full understanding of basic molecular genetic concepts as well as introduce the latest technologies and research strategies in the field of genomics. The development and application of technologies for whole-genome scanning of genetic variation and gene expression will be explored. Once human disease-associated genes are identified, researchers study how these genes normally act and what the consequences are when they have mutations. Students will learn about chromosomal and single gene disorders, gene cloning strategies, and the role of genetics in medicine. By 2003, the genome of numerous organisms have been sequenced, opening the door to comparative genomics and most importantly, providing important new organisms for the genetics study of human diseases. Students will also learn about important models for studying gene function, with an emphasis on the mouse as a model for cancer. Basic information about gene function in health and disease also provides a basis for human gene therapy. The primary focus of this module is to better understand the structure and function of genomes in normal and disease states. Outline
Module 4 Module Director: Tsonwin,
Hai, Ph.D. Associate Professor Neurobiotechnology Center and the Department of Molecular
and Cellular Biochemistry Textbook: Molecular Biology of the Cell, Fourth Edition, Editors: B. Alberts et al. Garland Science, 2002 Synopsis: The goal of this module is three fold. First, to review key areas in the regulation of eukaryotic gene expression. This includes transcriptional regulation by transcription factors and chromatin remodeling, pre-mRNA processing, mRNA turnover and surveillance, nuclear transport, and translational regulation. When appropriate, we will point out the links between these cellular processes and processes covered by other modules, such as the link between transcription and cell cycle regulation. Second, to describe the logic and methods used by the scientists to make some of the seminal discoveries in the fields. The hope is that by understanding the "process of discovery" not just the "discovery per se", the students will be able to develop their own process and make seminal discoveries in the future. In addition, by learning what the seminal discoveries were in the fields and how they affected our understanding today, the students will develop their own perspective and be able to see what is important and what is not. Third, to describe these fundamental cellular process in the context of human diseases. By learning how dysfunction of these cellular processes may lead to human diseases, the students can understand human diseases at the molecular level, a key element for a successful career in molecular medicine. Outline Promoter analysis and DNA-protein interaction (T. Hai) Transcription factors and co-factors (T. Hai) Assembly of the transcription machinery (T. Hai) Regulation and Complexity:
Analyses of methods and a review (T. Hai) Chromatin structure (Dr. Sif) Chromatin binding proteins and gene silencing (Dr. Sif) Regulation of chromatin structure (Dr. Sif) Biochemistry of splicing and 3’ processing (D. Schoenberg) Regulation of splicing and 3’ processing (D. Schoenberg) Integration of pre-mRNA processing with transcription (D. Schoenberg) mRNA turnover (D. Schoenberg ) mRNA surveillance (D. Schoenberg ) RNAi (Dr. Schoenberg) Nuclear Transport (K. Boris-Lawrie) mRNA Translation (K. Boris-Lawrie)Course Coordinators: Class Time: Two hours per week Synopsis: This course is designed to provide students with insight into the potential ethical dilemmas associated with biomedical research, and provide a basis for making decisions when faced with an ethical problem. The class will meet for 2 hours each week. Participants, both student and faculty, will be given specific cases and will discuss the issues raised by these cases. The topics that will be covered include: 1. Experimental design, data selection,
and record keeping; The course will be graded on a satisfactory/unsatisfactory
basis, based on class participation. WINTER QUARTER Biology
of Human Disease-II Course Coordinator: R. Thomas Boyd, Ph.D., Associate Professor, Department of Neuroscience Class Time: Two hours per day;
five days per week Synopsis: This is the second of a three-course sequence. Each course spans one quarter (ten weeks) and consists of four modules, each with its own theme. Most of the classes are lectures, but there are some group discussions and demonstrations. The overall goal is to provide sufficient breadth and depth of information for the students to understand at several levels of organization the causes and biological mechanisms responsible for the expression of different types of human diseases. During Winter Quarter, mechanisms involving subcellular structures, signaling within and between cells and their environment, and cell division are covered. This is done by first providing information about normal structure and function, and then explaining how abnormalities in these lead to disease. IBGP students register for all four (4) modules in IBGP 702.05. Non-IBGP students can also register for IBGP 702.05 or take individual modules. Module 5 Module Director: Beth Lee, Ph.D., Assistant Professor, Department of Physiology and Cell Biology Faculty: Richard W. Burry, Ph.D., Associate Professor, Department of Neuroscience Ross E. Dalbey, Ph.D., Professor, Department of Chemistry John J. Enyeart, Ph.D., Professor, Department of Pharmacology Sissy Jhiang, Ph.D., Associate Professor, Department of Physiology and Department of Internal Medicine Sumei Liu, Ph.D., Assistant Professor, Department of Physiology and Cell Biology Douglas R. Pfeiffer, Ph.D., Professor, Department of Molecular and Cellular Biochemistry Thomas W. Prior, Ph.D., Professor, Department of Pathology John M. Robinson, Ph.D., Professor, Department of Physiology and Cell Biology Allan J. Yates, M.D., Ph.D., Professor, Department of Pathology Mike X. Zhu, Ph.D., Assistant Professor, Department of Neuroscience Textbook: Molecular Biology of the Cell, Fourth Edition; Editors: B. Alberts et al. Garland Science, 2002 Synopsis: Normal cellular function is exquisitely dependent upon the coordinated activities of different types of subcellular organelles, including several membrane systems. Disruption of any of these can lead to cellular changes that ultimately can be expressed as disease at any level from the biochemical through to the whole body. This module will explore the normal functions of the major organelles and membrane systems outside of the nucleus, and how they can become involved in disease processes. Outline Ultrastructure of the cell (R. W. Burry) Structure and composition of membranes (A. J. Yates)
Membrane transport mechanisms (S. Jhiang) Diseases of membrane transporters (S. Liu) Membrane biophysics (S. Liu)
Transmembrane Channels (J. J. Enyeart)
Calcium regulation (M. X. Zhu) Protein translocation (R. E. Dalbey) Endocytosis and lysosomal function (J. M. Robinson) Glycobiology (A. J. Yates) Mitochondrion
Module 6 Module Director: Norton H. Neff, Ph.D., Professor, Department of Pharmacology Faculty: N.H. Neff, Ph.D. Professor, Department of Pharmacology K. Mykytyn, Ph.D. Assistant Professor, Department of Pharmacology R. Briesewitz, Ph.D. Assistant Professor, Department f Pharmacology G. Tejwani, Ph.D. Associate Professor, Department of Pharmacology H. Gu, Ph.D., Associate Professor, Department of Pharmacology D. Saffen, Ph.D. Associate Professor, Department of Pharmacology Textbook: There are several textbook that cover m |
