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Research interestsResearch area: Research in the Vascular Bioengineering Laboratory (Dr. Alevriadou’s lab) focuses on the effect of hemodynamic forces (fluid shear stress) or oxidative stress on: (a) the intracellular signal transduction, gene expression and protein synthesis of vascular endothelial cells, and (b) the molecular mechanisms of adhesive interactions between blood cells and other blood cells, vascular cells or extracellular matrices. Our immediate goal is to understand the role of endogenous reactive oxygen species in cultured endothelial cell dysfunction when exposed to changes in both oxygen tension and fluid flow. The long-term objective is to propose better prevention and treatment strategies for cardiovascular diseases, in particular for the ischemia/reperfusion-induced vascular injury.
Contact info
Address: 610 Davis Heart & Lung Research Institute 473 W. 12th Ave Columbus, OH 43210 Phone: 614-292-5160 Email: rita@ibgp.org
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